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pfizer obtained cp31398  (Pfizer Inc)

 
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    Structured Review

    Pfizer Inc pfizer obtained cp31398
    Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes <t>CP31398,</t> APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com
    Pfizer Obtained Cp31398, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pfizer+obtained+cp31398/pmc13053732-626-0-0?v=Pfizer+Inc
    Average 86 stars, based on 1 article reviews
    pfizer obtained cp31398 - by Bioz Stars, 2026-07
    86/100 stars

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    1) Product Images from "p53: from understanding its structure to advances in therapeutic targeting"

    Article Title: p53: from understanding its structure to advances in therapeutic targeting

    Journal: Signal Transduction and Targeted Therapy

    doi: 10.1038/s41392-025-02549-5

    Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes CP31398, APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com
    Figure Legend Snippet: Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes CP31398, APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com

    Techniques Used: Mutagenesis



    Similar Products

    pfizer obtained cp31398  (Pfizer Inc)
    86
    Pfizer Inc pfizer obtained cp31398
    Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes <t>CP31398,</t> APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com
    Pfizer Obtained Cp31398, supplied by Pfizer Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pfizer+obtained+cp31398/pmc13053732-626-0-0?v=Pfizer+Inc
    Average 86 stars, based on 1 article reviews
    pfizer obtained cp31398 - by Bioz Stars, 2026-07
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes CP31398, APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com

    Journal: Signal Transduction and Targeted Therapy

    Article Title: p53: from understanding its structure to advances in therapeutic targeting

    doi: 10.1038/s41392-025-02549-5

    Figure Lengend Snippet: Small-molecule drugs targeting p53 in cancer. a Small-molecule drugs that target tumors with missense mutant p53 include those that act broadly on multiple p53 mutants and those that act specifically on the p53 mutant. The former includes CP31398, APR-246, etc., and the latter includes PC14586, which targets the p53 Y220C mutant, etc.). b Small-molecule drugs that target wild-type p53 tumors mainly include MDM2 inhibitors, MDM4 inhibitors, and MDM2 and MDM4 inhibitors. c Small-molecule drugs that deplete mutant p53 include HDAC inhibitors, HSP90 inhibitors, and statins. This figure was created by BioRender.com

    Article Snippet: Pfizer obtained CP31398 by screening a synthetic compound library.

    Techniques: Mutagenesis